Product Name :Histone H4 (Acetyl-K91) polyclonal antibody
Reactivity :Human,Mouse,Rat,Other (Wide Range)
Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200
Background :Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Histone H4 (Acetyl-K91) polyclonal antibody detects endogenous levels of Histone H4 protein only when acetylated at Lys91.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Examples of Crosstalk Between Post-translational Modifications,
Alternative Name :FO108;H4;H4/n;H4F2;H4FN;HIST2H4
Immunogen :A synthetic Peptide of human Acetyl-Histone H4-K91
