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DNM1L polyclonal antibody

货号: BS7390

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7390

Product Name :DNM1L polyclonal antibody

Swiss-Prot :O00429

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:1000~1:3000 IF: 1:50~1:200

Background :This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DNM1L polyclonal antibody detects endogenous levels of DNM1L protein.

BiowMW :~82 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNM1L; DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV

Immunogen :Recombinant protein of human DRP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of A549 cells, using DRP1 antibody at 1:1000 dilution.

Western blot analysis of extracts of various cell lines, using DRP1 antibody at 1:500 dilution.

Immunofluorescence analysis of NIH/3T3 cells using DRP1 pAb at dilution of 1:50 (40x lens).

Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction

JournalAntioxidants & Redox Signaling

ApplicationIF,WB

IF5.828

SpeciesRat,Human

PMID26869350
Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

JournalJournal Of Molecular And Cellular Cardiology

ApplicationWB

IF5.055

SpeciesRat,Human

PMID26196303
Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

JournalMolecular And Cellular Endocrinology

ApplicationWB,IHC

IF3.693

SpeciesMouse

PMID27276511
Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

JournalEuropean Journal Of Pharmacology

ApplicationICC

IF3.17

SpeciesRat

PMID28743390
Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway

JournalPharmacological Research

ApplicationIF,WB

IF5.574

SpeciesHuman

PMID30471409