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DHX58 polyclonal antibody

货号: BS72386

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72386

Product Name :DHX58 polyclonal antibody

Swiss-Prot :Q96C10

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200

Background :Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DHX58 polyclonal antibody detects endogenous levels of DHX58 protein.

BiowMW :~ 77 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :D11LGP2;D11lgp2e;LGP2;RLR-3

Immunogen :Recombinant protein of human DHX58

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using DHX58 antibody.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）