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HLA-DRB1 polyclonal antibody

货号: BS72366

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72366

Product Name :HLA-DRB1 polyclonal antibody

Swiss-Prot :P01911/P01912/Q29974

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:100

Background :HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HLA-DRB1 polyclonal antibody detects endogenous levels of HLA-DRB1 protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DRB1;HLA-DR1B;HLA-DRB;SS1

Immunogen :Recombinant protein of human HLA-DRB1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using HLA-DRB1 antibody.

Immunofluorescence analysis of A549 cells using HLA-DRB1 antibody.

免疫沉淀（IP）

免疫组织化学（IHC）