产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

HUS1 polyclonal antibody

货号: BS71950

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS71950

Product Name :HUS1 polyclonal antibody

Swiss-Prot :O60921

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200

Background :The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HUS1 polyclonal antibody detects endogenous levels of HUS1 protein.

BiowMW :35kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Checkpoint protein HUS1; hHUS1; HUS1 (S. pombe) checkpoint homolog; Hus1; HUS1 checkpoint homolog (S. pombe); HUS1 Checkpoint Protein; HUS1 protein; HUS1+ - like protein; HUS1_HUMAN; Hydroxyurea-sensitive 1, S. pombe, homolog of;

Immunogen :Recombinant protein of human HUS1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using HUS1 antibody at 1:1000 dilution.

Immunofluorescence analysis of U20S cell using HUS1 antibody. Blue: DAPI for nuclear staining.

Immunoprecipitation analysis of 200ug extracts of 293T cells using 1ug HUS1 antibody at a dilition of 1:1000.