Product Name :DDR2 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB 1:500 - 1:2000
ELISA 1:5000-1:10000
Background :Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :DDR2 polyclonal antibody detects endogenous levels of DDR2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CD_antigen: CD167b; NTRKR3; TKT; TYRO10; Discoidin domain-containing receptor 2
Immunogen :KLH conjugated synthetic peptide derived from human CD167b: 245-350/855 <Extracellular>
Modification :Unmodification
