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F12 (HC) polyclonal antibody（KU）

货号: BS7026

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS7026

Product Name :F12 (HC) polyclonal antibody（KU）

Swiss-Prot :P00748

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :F12 (HC) polyclonal antibody detects endogenous levels of Coagulation factor XIIa heavy chain protein.

BiowMW :~ 68 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Coagulation factor XII; Hageman factor; HAF; Coagulation factor XIIa heavy chain;

Immunogen :Recombinant full length Human F12 (HC).

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of F12 (HC) pAb at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug) Lane3:AML-12 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug)