Product Name :Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1D12)
Application_all :ELISA 0.06-125 ng/mL
Background :Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several cancer types. Anti-MMAE antibody is a rabbit monoclonal antibody specially react with MMAE without MMAF, which is more sensitive than mouse antibody. The anti-MMAE antibody is a useful reagent in PK assay to determine conjugated antibodies.
Product :Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Purification&Purity :Protein A purified / Protein G purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Specifically recognizes MMAE and does not recognize MMAF.
Note :For research use only, not for use in diagnostic procedure.
