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IL1 beta polyclonal antibody

货号: BS65005

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS65005

Product Name :IL1 beta polyclonal antibody

Swiss-Prot :P01584

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL1 beta polyclonal antibody detects endogenous levels of IL1 beta protein.

BiowMW :~ 17,35kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,Inflammasonme Signaling,Necrotic Cell Death,

Alternative Name :IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B

Immunogen :Synthetic peptide, corresponding to Human IL1 beta.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of IL-1 beta expression in Raw264.7 (A), mouse spleen (B), rat spleen (C), rat thymus (D), mouse thymus (E), Jurkat (F), THP1 (G) whole cell lysates.

Immunohistochemical analysis of IL-1 beta staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system.

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