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ERBB3 (phospho-Y1328) polyclonal antibody

货号: BS64082

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64082

Product Name :ERBB3 (phospho-Y1328) polyclonal antibody

Swiss-Prot :P21860

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-ERBB3(Y1328) polyclonal antibody pAbdetects endogenous levels of ERBB3 protein around the phosphorylation site of Y1328.

BiowMW :~ 148 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1); Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

Immunogen :A synthetic peptide corresponding to residues in Human ERBB3 around the phosphorylation site of Y1328.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-ERBB3(Y1328) polyclonal antibody pAb at 1:500 dilution Lane1:MCF-7 treated with EGF(0.1ng/m) 30 min whole cell lysate Lane2:THP-1 treated with EGF(0.1ng/m) 30 min whole cell lysate Lane3:Raw264.7 treated with EGF(0.1ng/m) 30 min whole cell lysate