Product Name :ErbB-4 / HER4 (phospho-Y1284) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:2000
Background :The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-HER4(Y1284) polyclonal antibody detects endogenous levels of HER4 protein only when phosphorylated at Tyr1284.
Note :For research use only, not for use in diagnostic procedure.
Pathway :ErbB HER Signaling,
Alternative Name :4ICD; Avian erythroblastic leukemia viral oncogene homolog 4; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4; E4ICD; EC 2.7.10.1; ErbB4; ERBB4 intracellular domain; ERBB4; HER 4; HER4; Mer4; MGC138404; Oncogene ERBB4; P180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor protein tyrosine kinase erbB 4 precursor; Receptor tyrosine protein kinase erbB 4; s80HER4; Tyrosine kinase type cell surface receptor HER4; Tyrosine kinase-type cell surface receptor HER4; v erb a avi
Immunogen :Synthetic phosphopeptide derived from human ErbB-4 / HER4 around the phosphorylation site of Tyrosine 1284.
Modification :Phosphorylation
