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IL18BP polyclonal antibody

货号: BS6312

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS6312

Product Name :IL18BP polyclonal antibody

Swiss-Prot :O95998

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background :IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-β, respectively, over the twelve β-strands of the β-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-γ-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-γ production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL18BP polyclonal antibody detects endogenous levels of IL18BP protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa; IL18BP

Immunogen :Recombinant full length Human IL18BP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using IL18BP antibody.

Immunohistochemistry of paraffin-embedded mouse heart using IL18BP antibody at dilution of 1:100 (40x lens).

Immunofluorescence analysis of A549 cell using IL18BP antibody. Blue: DAPI for nuclear staining.

免疫沉淀（IP）