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IkB-α/NFKBIA polyclonal antibody

货号: BS6227

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6227

Product Name :IkB-α/NFKBIA polyclonal antibody

Swiss-Prot :P25963

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB 1:500 - 1:2000

Background :Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation Serines 32 and 36. IKKα appears to be critical for NFκB activation in response to proinflammatory cytokines. Phosphorylation of IκB by IKKα is stimulated by the NFκB inducing kinase (NIK), which itself is a central regulator for NFκB activation in response to TNF and IL-1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NFKBIA polyclonal antibody detects endogenous levels of NFKBIA protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :NF-kB Signaling,STING Signaling,

Alternative Name :NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA; MAD3; NFKBI

Immunogen :Recombinant full length Human IkB-α/NFKBIA.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of IkB-α polyclonal antibody in extracts from HL60 cells.

The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice

JournalInternational Immunopharmacology

ApplicationWB

IF3.943

SpeciesMouse

PMID25614226
An engineered TNFR1-selective human lymphotoxin-alpha mutant delivered by an oncolytic adenovirus for tumor immunotherapy

JournalBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ApplicationWB

IF6.2

SpeciesHuman

PMID38492783