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IL6 polyclonal antibody

货号: BS62100

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62100

Product Name :IL6 polyclonal antibody

Swiss-Prot :P05231

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells . IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization . gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade . IL-6 also forms a complex with an IL-6Rα splice variant that is nonmembrane-associated . The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα . Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL6 polyclonal antibody detects endogenous levels of IL6 protein.

BiowMW :~ 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; IL6; IFNB2

Immunogen :Synthetic peptide, corresponding to Human IL6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IL6 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:HuT78 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug)