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HNF-4α/γ polyclonal antibody

货号: BS61772

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61772

Product Name :HNF-4α/γ polyclonal antibody

Swiss-Prot :P41235/Q14541

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HNF-4α/γ polyclonal antibody detects endogenous levels of HNF-4α/γ protein.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,

Alternative Name :Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4; HNF4A; HNF4; NR2A1; TCF14; Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2; HNF4G; NR2A2

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human HNF-4α.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HNF-4α/γ polyclonal antibody at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:K562 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug) Lane5:A549 whole cell lysate(40ug)