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EIF3L polyclonal antibody

货号: BS61567

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61567

Product Name :EIF3L polyclonal antibody

Swiss-Prot :Q9Y262

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3å, eIF3∫, eIF3©, eIF3∂, eIF3ε, eIF3Ω, eIF3η and eIF3†, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EIF3L polyclonal antibody detects endogenous levels of EIF3L protein.

BiowMW :~ 66 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Eukaryotic translation initiation factor 3 subunit L; eIF3l; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein

Immunogen :Synthetic peptide, corresponding to amino acids 4-48 of Human EIF3L

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of EIF3L polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:The Lung lysate of Mouse(40ug) Lane4:The Liver lysate of Rat(40ug)