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DUSP16 polyclonal antibody

货号: BS61547

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61547

Product Name :DUSP16 polyclonal antibody

Swiss-Prot :Q9BY84

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :DUSP16/MKP7 is a negative regulator of the JNK/SAPK family of stress-activated MAP kinases. It inhibits JNK-mediated signaling events by dephosphorylating threonine and tyrosine residues within the activation loop of JNK proteins, effectively preventing further activation of downstream effectors. DUSP16/MKP7 expression has been shown to be upregulated after oxidative stress, presumably as a means of supressing JNK activity in order to return the cells to a homeostatic state. DUSP16 is normally turned over at a high-rate in most cells, but the stability of the protein can be enhanced by Erk1/2-mediated phosphorylation on Ser446, indicating that activation of mitogenic signaling pathways can supress stress-response pathways via stabilization of a JNK phosphatase . Despite demonstrating a substrate preference towards JNK proteins, DUSP16/MKP7 has been shown to interact with other MAPK family members (Erk1/2, p38 MAPKs) as well as scaffolding proteins that may coordinate its activity and specificity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DUSP16 polyclonal antibody detects endogenous levels of DUSP16 protein.

BiowMW :~ 73 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Dual specificity protein phosphatase 16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7

Immunogen :Synthetic peptide, corresponding to amino acids 577-621 of Human DUSP16

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of DUSP16 polyclonal antibody at 1:500 dilution Lane1:The Kidney tissue lysate of Rat(40ug) Lane2:The Brain tissue lysate of Mouse(40ug) Lane3:SK-OVCAR3 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)