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GPX1 polyclonal antibody

货号: BS61511

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61511

Product Name :GPX1 polyclonal antibody

Swiss-Prot :P07203

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-1 plays an important role in the antioxidant defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature acrosome reaction in the epididymis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GPX1 polyclonal antibody detects endogenous levels of GPX1 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Glutathione peroxidase 1; GPx-1; GSHPx-1; Cellular glutathione peroxidase; GPX1

Immunogen :Synthetic peptide, corresponding to amino acids 47-92 of Human GPX1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GPX1 polyclonal antibody at 1:500 dilution Lane1:THP-1 whole cell lysate(60ug) Lane2:The Liver tissue lysate of Mouse(40ug) Lane3:The Liver tissue lysate of Rat(40ug)

Electromagnetic Fields Ameliorate Insulin Resistance and Hepatic Steatosis by Modulating Redox Homeostasis and SREBP-1c Expression in db/db Mice

JournalDiabetes Metabolic Syndrome and Obesity-Targets and Therapy

ApplicationWB

IF2.842

SpeciesMouse

PMID33727836
Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota–gut–brain axis

JournalFrontiers in Cellular and Infection Microbiology

ApplicationWB

IF6.073

SpeciesMouse

PMID36439235