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FOXO1/O3 polyclonal antibody

货号: BS61349

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS61349

Product Name :FOXO1/O3 polyclonal antibody

Swiss-Prot :Q12778/O43524

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors.FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FOXO1/O3 polyclonal antibody detects endogenous levels of FOXO1/O3 protein.

BiowMW :~ 70 to 82 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,

Alternative Name :Fork head domain transcription factor AFX1; AFX; AFX1; MLLT7; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1; FKHR; FOXO1A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdo

Immunogen :Synthetic peptide, corresponding to amino acids 290-335 of Human FOXO1/O3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FOXO1/O3 polyclonal antibody at 1:500 dillution Lane1:A549 whole cell lysate(40μg) Lane2:Hela whole cell lysate(40μg) Lane3:The Heart tissue lysate of Mouse(40μg)