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Alkaline Phosphatase (ALPL) polyclonal antibody

货号: BS6134

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6134

Product Name :Alkaline Phosphatase (ALPL) polyclonal antibody

Swiss-Prot :P05186

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200

Background :This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Alkaline Phosphatase (ALPL) polyclonal antibody detects endogenous levels of Alkaline Phosphatase (ALPL) protein.

BiowMW :80KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Alkaline phosphatase tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme

Immunogen :KLH-conjugated synthetic peptide of human Alkaline Phosphatase (ALPL).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Alkaline Phosphatase (ALPL) expression in U87MG (A) whole cell lysates.

Immunohistochemical analysis of Alkaline Phosphatase (ALPL) staining in mouse kidney formalin fixed paraffin embedded tissue section.

A novel missense mutation in the ALPL gene causes dysfunction of the protein

JournalMolecular Medicine Reports

ApplicationWB

IF2.952

SpeciesHuman

PMID28586049