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GADD45GIP1 polyclonal antibody

货号: BS61196

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61196

Product Name :GADD45GIP1 polyclonal antibody

Swiss-Prot :Q8TAE8

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :CRIF1, also known as GADD45GIP1, PLINP1, PRG6 or CKBBP2, is a 222 amino acid nuclear protein that plays a role in apoptosis control. Expressed in a variety of tissues, including heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach, CRIF1 functions as a negative regulator of G1 to S phase cell cycle production, specifically by working with GADD 45 proteins to inhibit the activity of cyclin-dependent kinases (Cdks). While overexpression of CRIF1 results in cell cycle arrest at the G1 phase, downregulation of CRIF1 by p53 in apoptotic cells promotes cell cycle progression and may be an important factor in tumor growth and metastasis. CRIF1 is subject to phosphorylation by casein kinase II, an event that is thought to decrease CRIF1 activity and promote cellular proliferation. Human CRIF1 shares 90% homology with its mouse counterpart, suggesting a conserved role between species.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GADD45GIP1 polyclonal antibody detects endogenous levels of GADD45GIP1 protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Growth arrest and DNA damage-inducible proteins-interacting protein 1; 39S ribosomal protein L59, mitochondrial; MRP-L59; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein; GADD45GIP1; MRPL59; PLINP1; PRG6

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CRIF1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of GADD45GIP1 polyclonal antibody at 1:500 dilution Line1:Hela whole cell lysate