Product Name :ADAMTS17 polyclonal antibody
Application_all :WB: 1:500~1:1000
Background :ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of Thrombospondin type-1 (TSP-1) motifs. ADAMTS-17 (ADAM metallopeptidase with Thrombospondin type-1 motif, 17) is a 1,095 amino acid secreted protein that belongs to the ADAMTS family. Expressed in liver, prostate, brain and in fetal lung, ADAMTS-17 has seven N-glycosylation sites and shares 56% sequence identity with a related family member, ADAMTS-19. ADAMTS-17 has a conserved cysteine residue in its cysteine-switch motif that, when bound to one zinc ion, inhibits the enzymatic activity of the protein.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ADAMTS17 polyclonal antibody detects endogenous levels of ADAMTS17 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17; ADAMTS17
Immunogen :Synthetic peptide, corresponding to Human ADAMTS17.
Modification :Unmodification
