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ANO1 polyclonal antibody

货号: BS61052

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS61052

Product Name :ANO1 polyclonal antibody

Swiss-Prot :Q5XXA6

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ANO1 polyclonal antibody detects endogenous levels of ANO1 protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2; ANO1; DOG1; ORAOV2; TAOS2; TMEM16A

Immunogen :A synthetic peptide corresponding to residues in Human ANO1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ANO1 polyclonal antibody at 1:500 Line1:HEK293T whole cell lysate Line2:Hela whole cell lysate Line3:H9C2 whole cell lysate Line4: