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Cytokeratin 14 polyclonal antibody

货号: BS60854

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS60854

Product Name :Cytokeratin 14 polyclonal antibody

Swiss-Prot :P02533

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity :Cytokeratin 14 polyclonal antibody detects endogenous levels of Cytokeratin 14 protein.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Keratin, type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14; KRT14

Immunogen :A synthetic peptide corresponding to residues in Human Cytokeratin 14.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cytokeratin 14 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:H9C2 whole cell lysate Lane3:Raw264.7 whole cell lysate

Ameloblasts serum-free conditioned medium: bone morphogenic protein 4-induced odontogenic differentiation of mouse induced pluripotent stem cells

JournalJournal of Tissue Engineering and Regenerative Medicine

ApplicationIF

IF3.963

SpeciesMouse

PMID23606575
Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis

JournalOncotarget

ApplicationIHC

IF0

SpeciesMouse

PMID25938540
PGD2/PTGDR2 Signaling Restricts the Self‐Renewal and Tumorigenesis of Gastric Cancer

JournalStem Cells

ApplicationIF

IF5.614

SpeciesHuman

PMID29604141