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FAF1 polyclonal antibody

货号: BS60844

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS60844

Product Name :FAF1 polyclonal antibody

Swiss-Prot :Q9UNN5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wild type but not lpr mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FAF1 polyclonal antibody detects endogenous levels of FAF1 protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FAS-associated factor 1; hFAF1; UBX domain-containing protein 12; UBX domain-containing protein 3A; FAF1; UBXD12; UBXN3A

Immunogen :A synthetic peptide corresponding to residues in Human FAF1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FAF1 polyclonal antibody at 1:500 dilution Line1:A549 whole cell lysate Line2:PC12 whole cell lysate Line3:sp20 whole cell lysate