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F5 polyclonal antibody

货号: BS60797

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60797

Product Name :F5 polyclonal antibody

Swiss-Prot :P12259

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin, and factors X, IX, V, and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Coagulation factor V (Factor V, FV, proaccelerin, labile factor) is a 2,196 amino acid, single chain glycoprotein that is cleaved by thrombin to yield an active, Ca2+ dependent dimer. This heterodimer is essential to the blood coagulation cascade. Together with catalytic Factor Xa and Ca2+ on the surface of platelets or endothelial cells, Factor Va coordinates in a prothrombinase complex, which mediates proteolysis of prothrombin into active thrombin. Due to both the procoagulant properties of Factor V in coordinating proteolytic activation of thrombin, and anticoagulant properties as a cofactor to activated protein C (APC), which selectively destroys FVa and FXa, alterations at the Factor V locus can contribute to hemorrhagic diathesis or thrombosis, respectively.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :F5 polyclonal antibody detects endogenous levels of F5 protein.

BiowMW :~ 252 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Coagulation factor V; Activated protein C cofactor; Proaccelerin, labile factor; F5

Immunogen :A synthetic peptide corresponding to residues in Human F5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of F5 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:PC12 whole cell lysate

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）