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HSD17B4 polyclonal antibody

货号: BS60710

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60710

Product Name :HSD17B4 polyclonal antibody

Swiss-Prot :P51659

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-β Estradiol 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-β Estradiol dehydrogenase type IV. It belongs to the 17β-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17β-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol β-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17β-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17β-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HSD17B4 polyclonal antibody detects endogenous levels of HSD17B4 protein.

BiowMW :~ 79 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2; HSD17B4; EDH17B4

Immunogen :A synthetic peptide corresponding to residues in Human HSD17B4

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HSD17B4 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate