产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

IL3RA polyclonal antibody

货号: BS60620-B

价格：￥ ——

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60620-B

Product Name :IL3RA polyclonal antibody

Swiss-Prot :P26951

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC

Application_all :WB: 1:3000~1:5000 IHC: 1:50~1:100

Background :IL3RA/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (βc) shared with receptors for other cytokines. IL3RA/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while βc alone does not bind to IL-3 appreciably. Together, IL3RA/CD123 and βc form the functional high-affinity receptor for IL-3. IL3RA/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA/CD123 has also been reported for other hematopoietic malignancies . It is considered as a valuable therapeutic target for these malignancies .

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL3RA polyclonal antibody detects endogenous levels of IL3RA protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD_antigen: CD123; IL3RA

Immunogen :Synthetic peptide, corresponding to Human IL3RA.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IL3RA polyclonal antibody at 1:5000 dilution Lane1:H9C2 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:U-87MG whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using IL3RA antibody at dilution of 1:20 (x40 lens).