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Fatty Acid Synthase polyclonal antibody

货号: BS6050

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6050

Product Name :Fatty Acid Synthase polyclonal antibody

Swiss-Prot :P49327

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC,IF

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background :Fatty acid biosynthesis is mediated by seven catalytic enzymes and an acyl carrier protein (ACP), to which various acyl intermediates are covalently attached. Fatty Acid Synthase (FAS) is the anabolic enzyme that contains the seven unique catalytic sites and mediates the conversion of acetyl-CoA and malonyl-CoA, in the presence of the cofactor NADPH, into long-chain saturated fatty acids, such as palmitate. Human Fatty Acid Synthase cDNA encodes a 2,504 amino acid protein. Catalytically active Fatty Acid Synthase is a homodimer. Human Fatty Acid Synthase mRNA is variably expressed with abundant levels present in brain, lung and liver. Fatty acid synthetic metabolism is abnormally elevated in tumor cells and may support cell growth or survival of malignant cancers.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FASN polyclonal antibody detects endogenous levels of FASN protein.

BiowMW :~ 270 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :[Acyl-carrier-protein] S acetyltransferase; [Acyl-carrier-protein] S malonyltransferase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; FAS; FAS; FASN; Fatty acid synthase; MGC14367; MGC15706; OA 519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; Sh

Immunogen :Recombinant full length Human Fatty Acid Synthase.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of FASN polyclonal antibody in extracts from Hela, Molt-4 and 293T cells.

Immunoprecipitation analysis of 200ug extracts of 293T cells, using 3 ug FASN antibody.

Fatty Acid Transport in Saccharomyces cerevisiae: DIRECTED MUTAGENESIS OF FAT1 DISTINGUISHES THE BIOCHEMICAL ACTIVITIES ASSOCIATED WITH Fat1p *

JournalJournal Of Biological Chemistry

ApplicationWB

IF5.157

Speciesyeast

PMID12052836
Adipokine zinc-α2-glycoprotein alleviates lipopolysaccharide-induced inflammatory responses through the β3-AR/PKA/CREB pathway

JournalCytokine

ApplicationWB

IF2.952

SpeciesMouse

PMID31260855
Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice

JournalEndocrine Journal

ApplicationWB

IF1.952

SpeciesMouse

PMID32863292
Transcriptomics and metabolomics revealed the pulmonary protective mechanism of Xixin-Ganjiang Herb Pair for warming the lungs to dissolve phlegm in COPD rats

JournalJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

ApplicationWB

IF3.318

SpeciesRat

PMID