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HIC2 polyclonal antibody

货号: BS60430

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60430

Product Name :HIC2 polyclonal antibody

Swiss-Prot :Q96JB3

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HIC2 polyclonal antibody detects endogenous levels of HIC2 protein.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Hypermethylated in cancer 2 protein; Hic-2; HIC1-related gene on chromosome 22 protein Hic-3; Zinc finger and BTB domain-containing protein 30; HIC2; HRG22; KIAA1020; ZBTB30

Immunogen :A synthetic peptide corresponding to residues in Human HIC2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HIC2 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate