产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

CIC polyclonal antibody

货号: BS60283

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60283

Product Name :CIC polyclonal antibody

Swiss-Prot :Q96RK0

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Capicua, also referred to as CIC, is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CIC polyclonal antibody detects endogenous levels of CIC protein.

BiowMW :~ 164 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein capicua homolog; CIC; KIAA0306

Immunogen :A synthetic peptide corresponding to residues in Human CIC.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CIC polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate