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ADAMTS2 polyclonal antibody

货号: BS60092

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS60092

Product Name :ADAMTS2 polyclonal antibody

Swiss-Prot :O95450

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-2 cleaves the propeptides of Collagen Type I and II, but not Collagen Type III, prior to fibril assembly. It may also play a role in development aside from collagen biosynthesis. ADAMTS-2 is secreted and associated with the extracellular matrix, with the highest levels in skin, bone, tendon and aorta. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type VIIC (EDS VIIC), a recessively inherited connective-tissue disorder characterized clinically by severe skin fragility and joint hypermobility.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ADAMTS2 polyclonal antibody detects endogenous levels of ADAMTS2 protein.

BiowMW :~ 135 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI; PCINP; PCPNI

Immunogen :A synthetic peptide corresponding to residues in Human ADAMTS2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ADAMTS2 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate