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ID1 polyclonal antibody

货号: BS60047

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60047

Product Name :ID1 polyclonal antibody

Swiss-Prot :P41134

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ID1 polyclonal antibody detects endogenous levels of ID1 protein.

BiowMW :~ 16 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; ID1; BHLHB24; ID

Immunogen :A synthetic peptide corresponding to residues in Human ID1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ID1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat iver tissue lysate

Activation of yes‐associated protein mediates sphingosine‐1‐phosphate–induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms

JournalJournal Of Cellular Physiology

ApplicationWB

IF5.546

SpeciesRat

PMID33283886
SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway

JournalCellular Physiology And Biochemistry

ApplicationWB

IF0

SpeciesRat

PMID30453304