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HMGN1 polyclonal antibody

货号: BS60043

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60043

Product Name :HMGN1 polyclonal antibody

Swiss-Prot :P05114

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates. HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence. Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber. In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development .

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HMGN1 polyclonal antibody detects endogenous levels of HMGN1 protein.

BiowMW :~ 11 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Non-histone chromosomal protein HMG-14; High mobility group nucleosome-binding; domain-containing protein 1; HMGN1; HMG14

Immunogen :A synthetic peptide corresponding to residues in Human HMGN1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HMGN1 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:H9C2 whole cell lysate