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FOXN1 polyclonal antibody

货号: BS60036

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60036

Product Name :FOXN1 polyclonal antibody

Swiss-Prot :O15353

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXN1, also designated Transcription factor winged-nude (WHN), is required for keratinocyte growth, as well as differentiation of epithelial progenitor cells in the thymic primordium into subcapsular, cortical, and medullary epithelial cells of the mature thymus. Mutations in the FOXN1 gene are responsible for nude, immune-deficient mice and rats. These nude mice are useful as hosts for xenografts in cancer research. The promoters for FOXN1 are active in the skin and thymus reflecting the critical role FOXN1 plays in the proper development of these tissues. Secreted Wnt glycoproteins appear to regulate FOXN1 transcription in the thymus. FOXN1 is expressed in the embryonic thymus after the common primordium is formed, beginning at E11.25. FOXN1 is also expressed at very low levels in normal human kidney and thyroid gland. In human, it is also expressed in the differentiating cells of the hair follicle precortex, the innermost layer of the outer root sheath, and the thymus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FOXN1 polyclonal antibody detects endogenous levels of FOXN1 protein.

BiowMW :~ 69 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Forkhead box protein N1; Winged-helix transcription factor nude; FOXN1; RONU; WHN

Immunogen :A synthetic peptide corresponding to residues in Human FOXN1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FOXN1 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate