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IGF-1R polyclonal antibody

货号: BS5763

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5763

Product Name :IGF-1R polyclonal antibody

Swiss-Prot :P08069

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IGF-1R polyclonal antibody detects endogenous levels of IGF-1R protein. This antibody may cross-reacts with insulin receptor protein.

BiowMW :~ 95,155 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Insulin &Glucose Signaling,

Alternative Name :Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; IGF1R

Immunogen :Synthetic peptide, corresponding to amino acids 1165-1210 of Human IGF-1R.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IGF1R polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:sp2/0 cell lysate Lane3:NIH-3T3 cell lysate

Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB

JournalJournal Of Experimental & Clinical Cancer Research

ApplicationWB,IHC

IF11.161

SpeciesMouse,Human

PMID22217202
Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla

JournalStem Cell Research

ApplicationICC

IF4.489

SpeciesHuman

PMID22286010
MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R

JournalPLoS One

ApplicationWB

IF2.74

SpeciesHuman

PMID22073238