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FSHR polyclonal antibody

货号: BS5724

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5724

Product Name :FSHR polyclonal antibody

Swiss-Prot :P23945

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200

Background :Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FSHR polyclonal antibody detects endogenous levels of FSHR protein.

BiowMW :~ 78 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; LGR1

Immunogen :Synthetic peptide, corresponding to amino acids 330-375 of Human FSHR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FSHR pAb at 1:500 dilution Lane1:A2780 whole cell lysate(20ug) Lane2:SK-OVCAR3 whole cell lysate(20ug) Lane3:The Testis tissue lysate of Mouse(40ug) Lane4:The Ovary tissue lysate of Rat(40ug)

Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression

JournalScientific Reports

ApplicationICC

IF4.011

SpeciesRat

PMID25558795
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice

JournalScience Of The Total Environment

ApplicationIF,WB

IF6.551

SpeciesMouse

PMID32758727
Cross-talk between NOTCH2 and BMP4/SMAD signaling pathways in bovine follicular granulosa cells

JournalTHERIOGENOLOGY

ApplicationIF

IF2.74

SpeciesBovine

PMID35512514
Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome

JournalJournal of Clinical Medicine

ApplicationWB

IF4.964

SpeciesRat

PMID36233452
YTHDF2 as a Mediator in BDNF-Induced Proliferation of Porcine Follicular Granulosa Cells

JournalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ApplicationIF

IF5.6

SpeciesHuman

PMID38397033