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CYP2D6 (R450) polyclonal antibody

货号: BS5685

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5685

Product Name :CYP2D6 (R450) polyclonal antibody

Swiss-Prot :P10635

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Enhanced CYP2D6 activity has been related to malignancies of the bladder, liver, pharynx, and stomach and, especially, to cigarette-smoking-induced lung cancer. The data suggests that enhanced CYP2D6-mediated metabolism of one or more dietary and other environmental agents, to form a reactive intermediate, plays a role in cancer initiation and/or promotion in various tissues. CYP2D6 polymorphism, which is responsible for the variation in metabolism of debrisoquine 4-hydroxylase, is important in the metabolism of more than 30 drugs and environmental chemicals, including as much as 20% of all commonly prescribed drugs.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CYP2D6 (R450) polyclonal antibody detects endogenous levels of CYP2D6 protein.

BiowMW :~ 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cytochrome P450 2D6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase; CYP2DL1

Immunogen :Synthetic peptide, corresponding to amino acids 430-475 of Human CYP2D6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CYP2D6 (R450) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:NIH-3T3 cell lysate Lane3:H9C2 cell lysate

Species Difference in the Metabolism of Mulberrin in Vitro and Its Inhibitory Effect on Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes

JournalCHEMICAL & PHARMACEUTICAL BULLETIN

ApplicationWB

IF1.903

SpeciesHuman

PMID36184449