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HSD11B1 polyclonal antibody

货号: BS5588

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5588

Product Name :HSD11B1 polyclonal antibody

Swiss-Prot :P28845

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Glucocorticoid hormone action in target tissues is modulated by 11b-hydroxysteroid dehydrogenase (11b-HSD), which catalyzes the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone). At least two isoforms of 11b-HSD exist: a low-affinity NADP-dependent dehydrogenase/oxoreductase (11b-HSD1) and a high-affinity NAD-dependent dehydrogenase (11b-HSD2). The glycosylated 11b-HSD1 protein activates cortisol from cortisone, which is widely expressed in mammals, and is most highly expressed in the liver. 11b-HSD1 may play a role in glucose homeostasis and pathogenesis of a number of disorders including insulin resistance and obesity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HSD11B1 polyclonal antibody detects endogenous levels of HSD11B1 protein.

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L; 11β-HSD1; 11β HSD1; 11βHSD1

Immunogen :Synthetic peptide, corresponding to amino acids 43-88 of Human HSD11B1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HSD11B1 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:H9C2 cell lysate Lane3:PC12 cell lysate

MicroRNA-130b attenuates dexamethasone-induced increase of lipid accumulation in porcine preadipocytes by suppressing PPAR-γ expression

JournalOncotarget

ApplicationWB

IF0

SpeciesPig

PMID29152131