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FoxO3A (phospho-S253) polyclonal antibody（KU）

货号: BS5019

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS5019

Product Name :FoxO3A (phospho-S253) polyclonal antibody（KU）

Swiss-Prot :O43524

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation.FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-FoxO3A (S253) polyclonal antibody detects endogenous levels of FoxO3A protein when phosphorylated at Ser253.

BiowMW :~ 80-95 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,

Alternative Name :Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3; FKHRL1; FOXO3A

Immunogen :Synthetic phosphopeptide derived from human FOXO3A around the phosphorylation site of Serine 253.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-FoxO3A (S253) pAb at 1:500 dilution Lane1:The Testis tissue lysate of Rat(40ug) Lane2:The Testis tissue lysate of Mouse(20ug) Lane3:Hela whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of p-FOXO3A (S253) pAb in paraffin-embedded human breast carcinoma tissue.

Effects of the beta2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia

JournalBiochimie

ApplicationWB

IF3.413

SpeciesRat

PMID