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GluR1 (phospho-S849) polyclonal antibody（KU）

货号: BS4792

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4792

Product Name :GluR1 (phospho-S849) polyclonal antibody（KU）

Swiss-Prot :P42261

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-GluR1 (S849) polyclonal antibody detects endogenous levels of GluR1 only when phosphorylated at Ser849.

BiowMW :~ 102 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; GluRA; GluRK1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1

Immunogen :Synthetic phosphopeptide derived from human GluR1 around the phosphorylation site of Serine 849.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-GluR1 (S849) pAb at 1:500 dilution Lane1:A375 whole cell lysate(40ug) Lane2:K562 whole cell lysate(40ug) Lane3:The Kidney tissue lysate of Mouse(40ug) Lane4:PC12 whole cell lysate(40ug)