产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Ezrin (phospho-T567)/Radixin (phospho-T564)/Moesin (phospho-T558) polyclonal antibody（KU）

货号: BS4717

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4717

Product Name :Ezrin (phospho-T567)/Radixin (phospho-T564)/Moesin (phospho-T558) polyclonal antibody（KU）

Swiss-Prot :P15311/P26038/P35241

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Ezrin(T567)/Radixin (T564)/Moesin (T558) polyclonal antibody detects endogenous levels of Ezrin, Radixin and Moesin only when phosphorylated at Thr567, Thr564 or Thr558, respectively.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of ECM and Cytoskeletal Factors to EMT,B cell receptor signaling,

Alternative Name :Ezrin; Cytovillin; Villin-2; Villin2; Villin 2; p81; EZR; VIL2; Moesin; Membrane-organizing extension spike protein; MSN; Radixin; RDX

Immunogen :Synthetic phosphopeptide derived from human Ezrin, Radixin, Moesin respectively are around the phosphorylation site of Threonine 567, 564, 558.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Ezrin (T566) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:A2780 whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug)