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FoxO3A (phospho-S253) polyclonal antibody

货号: BS4713

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4713

Product Name :FoxO3A (phospho-S253) polyclonal antibody

Swiss-Prot :O43524

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation.FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-FoxO3A (S253) polyclonal antibody detects endogenous levels of FoxO3A protein when phosphorylated at Ser253.

BiowMW :~ 97 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,

Alternative Name :Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3; FKHRL1; FOXO3A

Immunogen :Synthetic phosphopeptide derived from human FOXO3A around the phosphorylation site of Serine 253.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analyzes of p-FoxO3 (S253) polyclonal antibody in extracts from raw264.7 cells.

Immunohistochemistry (IHC) analyzes of p-FoxO3A (S253) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Follicle loss and PTEN/PI3K/mTOR signaling pathway activated in LepR-mutated mice

JournalGynecological Endocrinology

ApplicationWB

IF1.406

SpeciesMouse

PMID30145913