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APC (phospho-S2054) polyclonal antibody

货号: BS4649

价格：￥ 780

货期：现货（1-2个工作日）

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No. :BS4649

Product Name :APC (phospho-S2054) polyclonal antibody

Swiss-Prot :P25054

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates ß-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-APC (S2054) polyclonal antibody detects endogenous levels of APC protein when phosphorylated at Ser2054.

BiowMW :~ 310 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Contribution of Soluble Factors to EMT,

Alternative Name :Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC; DP2.5

Immunogen :Synthetic phosphopeptide derived from human APC around the phosphorylation site of Serine 2054.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-APC (S2054) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate