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DAPK3 (phospho-T265) polyclonal antibody（KU）

货号: BS4589

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4589

Product Name :DAPK3 (phospho-T265) polyclonal antibody（KU）

Swiss-Prot :O43293

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DAPK3 (phospho-T265) polyclonal antibody detects endogenous levels of DAPK3 protein when phosphorylated at Thr265.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Epigenetic Writers and Erasers of Histone H3,

Alternative Name :ZIPK; ZIP kinase; ZIP-kinase; ZIP; Dlk; Death associated protein kinase 3; Death associated kinase 3; Dapk3; Dapk 3; DAP like kinase; DAP kinase 3

Immunogen :Synthetic phosphopeptide derived from human DAPK3 around the phosphorylation site of Thr265.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-DAPK3 (T265) pAb at 1:500 dilution Lane1:Hela whole cell lysate(40µg) Lane2:SK-OVCAR3 whole cell lysate(40µg) Lane3:SGC7901 whole cell lysate(40µg) Lane4:3T3-L1 whole cell lysate(40µg) Lane5:PC12 whole cell lysate(40µg)