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c-Fos (phospho-S362) polyclonal antibody（KU）

货号: BS4540

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4540

Product Name :c-Fos (phospho-S362) polyclonal antibody（KU）

Swiss-Prot :P01100

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-c-Fos (S362) polyclonal antibody detects endogenous levels of c-Fos protein only when phosphorylated at Ser362

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :MAPK Erk in Growth and Differentiation Pathway,

Alternative Name :Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7; FOS; G0S7

Immunogen :Synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Serine 362.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-c-Fos (S362) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:Panc1 whole cell lysate(40ug) Lane3:The Brain tissue lysate of Mouse(40ug) Lane4:The Brain tissue lysate of Rat(40ug)