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ERβ (phospho-S105) polyclonal antibody（KU）

货号: BS4503

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4503

Product Name :ERβ (phospho-S105) polyclonal antibody（KU）

Swiss-Prot :Q92731

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ERβ (phospho-S105) polyclonal antibody detects endogenous levels of Erβprotein around the phosphorylation site of S105.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2; ESR2; ESTRB; NR3A2; ER-β

Immunogen :Synthetic peptide derived from human ERβaround the phosphorylation site of S105.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-ERβ (S105) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40µg) Lane2:SK-OVCAR3 whole cell lysate(40µg) Lane3:MCF-7 whole cell lysate(40µg) Lane4:PC3 whole cell lysate(40µg) Lane5:LO2 whole cell lysate(40µg)

Arctigenin functions as a selective agonist of estrogen receptor β to restrict mTORC1 activation and consequent Th17 differentiation

JournalOncotarget

ApplicationWB

IF0

SpeciesMouse

PMID27863380
Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases

JournalFaseb Journal

ApplicationWB,IF,IP

IF4.966

SpeciesHuman

PMID31908053