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GR (phospho-S211) polyclonal antibody（KU）

货号: BS4459

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS4459

Product Name :GR (phospho-S211) polyclonal antibody（KU）

Swiss-Prot :P04150

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-GR (S211) polyclonal antibody detects endogenous levels of GR protein only when phosphorylated at Ser211

BiowMW :~ 90,95 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,Nuclear Receptor Signaling,

Alternative Name :Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1; NR3C1; GRL

Immunogen :Synthetic phosphopeptide derived from human GR around the phosphorylation site of Serine 211.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-GR (S211) pAb at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:CT26 whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of p-GR (S211) pAb in paraffin-embedded human breast cancer tissue.

Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine

JournalJournal Of Ethnopharmacology

ApplicationWB

IF3.69

SpeciesHuman

PMID28729227