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Eg5 (phospho-T926) polyclonal antibody（KU）

货号: BS4428

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4428

Product Name :Eg5 (phospho-T926) polyclonal antibody（KU）

Swiss-Prot :P52732

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Eg5 (also called kinesin-like protein 11 or Kif11) belongs to the kinesin-like family of motor proteins important in chromosome positioning, centrosome separation, and mitotic spindle formation. Phosphorylation of Eg5 by mitotic kinases regulates its activity by modulating its association with microtubules. Because anti-mitotic chemotherapeutic drugs, such as taxanes, target microtubules and have pleiotropic and sometimes toxic effects, drugs that target microtubule-associated proteins such as Eg5 are currently in development.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Eg5 (T926) pAb detects endogenous levels of Eg5 protein only when phosphorylated at Thr926.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,

Alternative Name :Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; KIF11; EG5; KNSL1; TRIP5

Immunogen :Synthetic phosphopeptide derived from human Eg5 around the phosphorylation site of Threonine 926

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Eg5 (T926) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40µg) Lane2:HepG2 whole cell lysate(40µg) Lane3:CT-26 whole cell lysate(40µg) Lane4:C6 whole cell lysate(40µg) Lane5:LOVO whole cell lysate(40µg) Lane6:MCF-7 whole cell lysate(40µg)