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Dynamin-1 (phospho-S774) polyclonal antibody（KU）

货号: BS4228

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4228

Product Name :Dynamin-1 (phospho-S774) polyclonal antibody（KU）

Swiss-Prot :Q05193

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Dynamin-1 (S774) polyclonal antibody detects endogenous levels of Dynamin-1 protein when phosphorylated at Ser774.

BiowMW :~ 98 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Vesicle Trafficking presynaptic signaling,

Alternative Name :Dynamin 1; Dynamin1; DNM1; DNM; Dynamin I; Dynamin-I; DynaminI

Immunogen :Synthetic phosphopeptide derived from human Dynamin-1 around the phosphorylation site of Serine 774.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Dynamin I (S774) pAb at 1:1000 dilution Lane1:The Brain tissue lysate of Mouse(30ug) Lane2:The Brain tissue lysate of Rat(30ug) Lane3:U-87MG whole cell lysate(40ug)